Modulation of KCNQ1 alternative splicing regulates cardiac IKs and action potential repolarization
نویسندگان
چکیده
منابع مشابه
Modulation of KCNQ1 alternative splicing regulates cardiac IKs and action potential repolarization.
BACKGROUND Slow delayed-rectifier potassium current (IKs) channels, made of the pore-forming KCNQ1 and auxiliary KCNE1 subunits, play a key role in determining action potential duration (APD) in cardiac myocytes. The consequences of drug-induced KCNQ1 splice alteration remain unknown. OBJECTIVE To study the modulation of KCNQ1 alternative splicing by amiloride and the consequent changes in IK...
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Signal transducer and activator of transcription 3 (STAT3) plays a central role in the activation of multiple oncogenic pathways. Splicing variant STAT3β uses an alternative acceptor site within exon 23 that leads to a truncated isoform lacking the C-terminal transactivation domain. Depending on the context, STAT3β can act as a dominant-negative regulator of transcription and promote apoptosis....
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A subset of patients with dilated cardiomyopathy (DCM) have been shown to carry increased levels of autoantibodies againstb-adrenoceptors, muscarinic receptors, Na+–K+-ATPase, or troponin I. – 4 There is increasing evidence that these autoantibodies can have important electrophysiological consequences and may contribute to the arrhythmogenic risk of DCM patients. In this edition of Cardiovascul...
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BACKGROUND The role of IKs, the slow delayed rectifier K+ current, in cardiac ventricular repolarization has been a subject of debate. METHODS AND RESULTS We develop a detailed Markov model of IKs and its alpha-subunit KCNQ1 and examine their kinetic properties during the cardiac ventricular action potential at different rates. We observe that interaction between KCNQ1 and KCNE1 (the beta-sub...
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ژورنال
عنوان ژورنال: Heart Rhythm
سال: 2013
ISSN: 1547-5271
DOI: 10.1016/j.hrthm.2013.04.014